Premature ovarian failure

What is premature ovarian failure?

Premature ovarian failure (POF), also known as primary ovarian insufficiency, is a condition where the ovaries stop functioning properly before age 40. This results in loss of normal reproductive function due to low levels of hormones like estrogen and progesterone.

Some key facts about POF:

• It affects roughly 1% of women under age 40, and 0.1% under age 30


• The cause is often unknown, but can include genetics, autoimmune disorders, infections, cancer treatment, etc.


• Symptoms include irregular/missed periods, hot flashes, vaginal dryness, difficulty conceiving


• It is not reversible, but hormones can help manage symptoms

Diagnosing Premature Ovarian Failure

Doctors diagnose POF based on a woman's symptoms, medical history, physical exam, and blood tests measuring hormone levels. They may also recommend genetic testing or imaging tests to rule out other issues with reproductive organs.

Key blood tests include:

• FSH (follicle stimulating hormone)


• Estradiol


• AMH (anti-mullerian hormone)

These hormone levels are markedly different in women with POF compared to healthy menstruating women.

Treatment and Outlook

Although the loss of ovarian function is not reversible in POF, treatment can help:

• Hormone replacement therapy (HRT) with estrogen and progesterone to regulate hormones


• Medications to protect bone health


• Counseling and emotional support


• Treatment of infertility if desired

The team of doctors at Hormone Harmony Clinic specialize in effectively diagnosing and compassionately treating POF patients. They optimize hormone levels through cutting-edge therapies, reducing symptoms and improving quality of life. Their holistic approach also focuses on counseling, fitness, nutrition and community support.

While being diagnosed with POF is difficult, the condition is manageable with proper treatment. The outlook for living a happy, healthy, productive life is good. Connecting with Hormone Harmony Clinic() puts patients on the path to successfully navigating life with POF.